Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes
Kamal, Amany; Wasfey, Eman F; Elghamry, Wesam R; Sabry, Omar M; Elghobary, Hany A; Sara Mostafa Radwan;
Abstract
Accumulating evidences suggest that immune checkpoints (ICs) inhibit immune response against cancerous cells and promote tumor cell survival. Up-regulation of ICs in tumor microenvironment is reported in patients with colorectal cancer (CRC). Thus, evaluating the peripheral blood expression of ICs may be used as non-invasive biomarkers for diagnosis and prognosis of CRC.
Other data
| Title | Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes | Authors | Kamal, Amany ; Wasfey, Eman F; Elghamry, Wesam R; Sabry, Omar M; Elghobary, Hany A; Sara Mostafa Radwan | Keywords | BTLA; CTLA-4; Colorectal cancer; Gene expression; Immune checkpoints; LAG-3; TIM-3 | Issue Date | 1-Jul-2021 | Journal | Clinical Biochemistry | ISSN | 00099120 | DOI | 10.1016/j.clinbiochem.2021.06.007 | PubMed ID | 34217699 | Scopus ID | 2-s2.0-85110782073 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.