REACTION OF 2-IMINO-2H-CHROMENE-3-CARBOXAMIDE WITH PHOSPHORUS HALIDES: SYNTHESIS OF SOME NOVEL CHROMENO[2,3-d][1,3,2]DIAZAPHOSPHININES AND CHROMENO[4,3-c][1,2]-AZAPHOSPHOLE AND THEIR ANTIOXIDANT AND CYTOTOXICITY PROPERTIES
Ali, TE; Assiri, MA; Metwally El-Shaaer, Hafez; Fouda, AM; Hassan, MM; Hassanin, NM;
Abstract
Novel 1,2-azaphosphole and 1,3,2-diazaphosphinines containing a chromene ring have been obtained from the treatment of 2-imino-2H-chromene-3-carboxamide (1) with some phosphorus halides. The compounds were evaluated for antioxidant and cytotoxic activities. Among the synthesized compounds, compound 4 exhibited the most potent antioxidant agents in comparison with ascorbic acid as standard antioxidant. Also, compound 4 recorded potentially cytotoxicity against all four cell lines.
Other data
| Title | REACTION OF 2-IMINO-2H-CHROMENE-3-CARBOXAMIDE WITH PHOSPHORUS HALIDES: SYNTHESIS OF SOME NOVEL CHROMENO[2,3-d][1,3,2]DIAZAPHOSPHININES AND CHROMENO[4,3-c][1,2]-AZAPHOSPHOLE AND THEIR ANTIOXIDANT AND CYTOTOXICITY PROPERTIES | Authors | Ali, TE; Assiri, MA; Metwally El-Shaaer, Hafez ; Fouda, AM; Hassan, MM; Hassanin, NM | Keywords | REAGENTS SYNTHESIS;BEARING;OXIDATION;DERIVATIVES;1,2-AZAPHOSPHOLES | Issue Date | 2019 | Publisher | PERGAMON-ELSEVIER SCIENCE LTD | Journal | Heterocycles | ISSN | 0385-5414 | DOI | 10.3987/COM-19-14062 | Scopus ID | 2-s2.0-85069684067 | Web of science ID | WOS:000482504500006 |
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