Repurposing of erythropoietin as a neuroprotective agent against methotrexate-induced neurotoxicity in rats
Nadine C Sabry; Haidy E Michel; Effat, Haidy; Menze, Esther;
Abstract
Methotrexate (MTX) is a cytotoxic drug that can trigger neurotoxicity via enhancing oxidative stress, apoptosis, and inflammation. On the other hand, erythropoietin (EPO) functions as an antioxidant, anti-apoptotic, and anti-inflammatory agent, in addition to its hematopoietic effects.
Other data
| Title | Repurposing of erythropoietin as a neuroprotective agent against methotrexate-induced neurotoxicity in rats | Authors | Nadine C Sabry; Haidy E Michel; Effat, Haidy ; Menze, Esther | Keywords | Chemobrain; autophagy; erythropoietin; methotrexate; neurotoxicity | Issue Date | 1-Feb-2025 | Journal | Journal of psychopharmacology | ISSN | 0269-8811 1461-7285 |
DOI | 10.1177/02698811241295379 | PubMed ID | 39535118 | Scopus ID | 2-s2.0-85209117108 |
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