Dokla, Eman

emanelawady@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Rational design and computational modeling of small molecules targeting cancer‑related pathways, including kinase inhibitors, protein–protein interaction modulators, and epigenetic targets, Design, synthesis, and optimization of small‑molecule anticancer agents, with emphasis on dual‑target inhibitors and molecules modulating mitochondrial respiration and ER‑stress signaling, Development of novel antimicrobial agents and structural optimization toward lead identification and preclinical candidate advancement, Integration of structure‑based and ligand‑based drug design (docking, MD simulations, pharmacophore modeling, and virtual screening) to support discovery of bioactive small molecules across oncology and infectious disease indications,
Internal ID: rp11910

 
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Full Name
Dokla, Eman
 
 
 
WOS ID
 
Biography
Eman M.E. Dokla is an associate professor at the department of Pharmaceutical Chemistry, Ain Shams University, Egypt. Her current research interest focuses on targeted cancer therapy and the development of novel antimicrobial agents. She has co-authored several peer-reviewed papers on the discovery and development of small-molecule kinase inhibitors targeting breast cancer and acute myeloid leukemia, and protein degraders targeting breast, lung, and oral squamous cell cancers. In this context, her work comprises drug discovery and medicinal chemistry efforts for small-molecule inhibitors’ development and optimization.

Publications

Results 1-20 of 23 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
11-Dec-2025Tackling microbial resistance with 4H-chromen-4-one derivatives as a novel class of penicillin binding protein 2a inhibitorsShalaby, Menna-Allah W; Abutaleb, Nader S; Elgammal, Yehia; Liang, Hsin-Wen; Abdallah, Inas A; Fishovitz, Jennifer; Seleem, Mohamed N; Abouzid, Khaled A M; Serya, Rabah ; Dokla, Eman 
2May-2025Structural Optimization and MD Simulation Study of Benzimidazole Derivatives as Potent Mutant FLT3 Kinase Inhibitors Targeting AMLEl-Deen, Nada Alaa; DeFilippis, RosaAnna; Milik, Sandra N; Patel, Suhana; Ismail, Muhammad I; Khaled, Omar; Ahmed, Tarek Erfan; Abdelfattah, Ayatullah Gamal; Ali, Eslam M H; Gaballah, Maiy Y; McPhillie, Martin J; Abouzid, Khaled A M; Henary, Maged; Minucci, Saverio; Shah, Neil P; Abdel-Aziz, Amal Kamal ; Serya, Rabah ; Dokla, Eman 
32025Anticancer activity of EMD37 against human head and neck cancer: Impact on apoptotic and inflammatory machineriesMarwa Sharaky; Amal Kamal Abdel-Aziz; Dokla, Eman 
42025A synthetic molecule targeting STAT3 against human oral squamous cell carcinoma cellsLi-Yuan Bai; Po-Chen Chu; Chia-Hsien Feng; Jing-Lan Hu; Liang-Jun Wang; Jing-Ru Weng; Dokla, Eman 
515-Mar-2024Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cellsAbdel-Aziz, Amal Kamal ; Ahmed, Tarek E.; Hatem, Yasmin; Abdel Rahman, Engy A.; Sharaky, Marwa; Shahin, Mai I. ; Elrazaz, Eman Z.; Serya, Rabah A.T. ; Henary, Maged; Ali, Sameh S.; Abou El Ella, Dalal A.; Dokla, Eman ; Helmy, Sama 
62024FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectivesHeba M. Hesham; Eman Z. Elrazaz; Deena S. Lasheen; Dalal A. Abou El Ella; Dokla, Eman 
7Nov-2023FLT3 inhibitors and novel therapeutic strategies to reverse AML resistance: An updated comprehensive reviewAbdel-Aziz, Amal Kamal ; Saadeldin, Mona Kamal; Dokla, Eman 
82023Nanoemulgel formulation of a benzimidazole derivative for wound healingRiham I. El-Gogary; Nada M. Abd-Elsaid; Mariam Gad; Reem K. Abd-Elhalim; Hana H. Habib; Wesam Eldeeb; Esraa R. Eldahshan; Salma H. Nassar; Aya N. Issa; Neveen Rabeh; Samar Abd-Elkhalik; Maha Nasr; Dokla, Eman 
92023AML and FLT3: An update on FDA-approved or under review kinase inhibitors targeting FLT3 kinaseNada Alaa El-Deen; Mai Jaballah; Abouzid, Khaled ; Dokla, Eman ; Serya, Rabah 
1022-Dec-2022SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteriaDokla, Eman ; Abutaleb, Nader S; Milik, Sandra N; Kandil, Ezzat A E A; Qassem, Omar M; Elgammal, Yehia; Nasr, Maha ; McPhillie, Martin J; Abouzid, Khaled A M; Seleem, Mohamed N; Imming, Peter; Adel, Mai
11Dec-2022Discovery of EMD37, a 1,2,4-oxadiazole derivative, as a novel endoplasmic reticulum stress inducer with potent anticancer activityAbdel-Aziz, Amal Kamal ; Khaled A M Abouzid ; Minucci, Saverio; Dokla, Eman 
121-Jun-2022Induction of apoptosis using ATN as a novel Yes-associated protein inhibitor in human oral squamous cell carcinoma cellsChu, Po Chen; Dokla, Eman ; Hu, Jing Lan; Weng, Jing Ru
1315-Feb-2022Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemiaDokla, Eman ; Abdel-Aziz, Amal Kamal ; Milik, Sandra N.; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
141-Dec-2021Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancerDokla, Eman ; Abdel-Aziz, Amal Kamal ; Milik, Sandra N.; Mahmoud, Amr H.; Saadeldin, Mona Kamal; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
151-Aug-2020Penicillin binding protein 2a: An overview and a medicinal chemistry perspectiveShalaby, Menna-Allah W; Dokla, Eman ; Serya, Rabah ; Khaled A M Abouzid 
169-Apr-2020Targeting YAP Degradation by a Novel 1,2,4-Oxadiazole Derivative via Restoration of the Function of the Hippo PathwayDokla, Eman ; Fang, Chun Sheng; Chu, Po Chen; Chang, Chih Shiang; Chen, Ching S.; Khaled A M Abouzid 
1715-Jan-2020Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteriaAbutaleb, Nader S; Milik, Sandra N; Li, Daoyi; El-Baz, Karim; Shalaby, Menna-Allah W; Al-Karaki, Rawan; Nasr, Maha ; Klein, Christian D; Seleem, Mohamed N; Dokla, Eman ; Khaled A M Abouzid 
1815-Nov-20191,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLCDokla, Eman ; Fang, Chun Sheng; Chen, Ching S.; Abouzid, Khaled 
192019Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluationShalaby, Menna-Allah; Dokla, Eman ; Serya, Rabah ; Abouzid, Khaled 
201-Jul-2018A 5′ AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell CarcinomaWeng, Jing Ru; Dokla, Eman ; Bai, Li Yuan; Chen, Ching Shih; Chiu, Shih Jiuan; Shieh, Tzong Ming