Dokla, Eman

emanelawady@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Rational design and computational modeling of small molecules targeting cancer‑related pathways, including kinase inhibitors, protein–protein interaction modulators, and epigenetic targets, Design, synthesis, and optimization of small‑molecule anticancer agents, with emphasis on dual‑target inhibitors and molecules modulating mitochondrial respiration and ER‑stress signaling, Development of novel antimicrobial agents and structural optimization toward lead identification and preclinical candidate advancement, Integration of structure‑based and ligand‑based drug design (docking, MD simulations, pharmacophore modeling, and virtual screening) to support discovery of bioactive small molecules across oncology and infectious disease indications,
Internal ID: rp11910
  • 221 Scopus Citations
  • 50 PubMed Citations

 
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Full Name
Dokla, Eman
 
 
 
WOS ID
 
Biography
Eman M.E. Dokla is an associate professor at the department of Pharmaceutical Chemistry, Ain Shams University, Egypt. Her current research interest focuses on targeted cancer therapy and the development of novel antimicrobial agents. She has co-authored several peer-reviewed papers on the discovery and development of small-molecule kinase inhibitors targeting breast cancer and acute myeloid leukemia, and protein degraders targeting breast, lung, and oral squamous cell cancers. In this context, her work comprises drug discovery and medicinal chemistry efforts for small-molecule inhibitors’ development and optimization.

Publications

Results 21-23 of 23 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
21Nov-2015Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) ActivatorsFang, Chun-Sheng; Lai, Po-Ting; Kulp, Samuel K; Serya, Rabah ; Ismail, Nasser S M; Chen, Ching-Shih; Dokla, Eman ; Khaled A M Abouzid 
221-Dec-2013Ligand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino] phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino- acetamidobenzoic acid estersIsmail, Mohamed Abdel Hamid; Mohamed, Nasser Saad; Dokla, Eman ; Khaled A M Abouzid 
2327-Nov-2012Applying Ligands Profiling Using Multiple Extended Electron Distribution Based Field Templates and Feature Trees Similarity Searching in the Discovery of New Generation of Urea-Based Antineoplastic Kinase InhibitorsDokla, Eman ; Mahmoud, Amr H.; Elsayed, Mohamed S.A.; El-Khatib, Ahmed H.; Linscheid, Michael W.; Khaled A M Abouzid