Dokla, Eman

emanelawady@pharma.asu.edu.eg
Department of Pharmaceutical Chemistry - Pharmacy
Interests: Rational design and computational modeling of small molecules targeting cancer‑related pathways, including kinase inhibitors, protein–protein interaction modulators, and epigenetic targets, Design, synthesis, and optimization of small‑molecule anticancer agents, with emphasis on dual‑target inhibitors and molecules modulating mitochondrial respiration and ER‑stress signaling, Development of novel antimicrobial agents and structural optimization toward lead identification and preclinical candidate advancement, Integration of structure‑based and ligand‑based drug design (docking, MD simulations, pharmacophore modeling, and virtual screening) to support discovery of bioactive small molecules across oncology and infectious disease indications,
Internal ID: rp11910
  • 221 Scopus Citations
  • 50 PubMed Citations
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Full Name
Dokla, Eman
 
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Biography
Eman M.E. Dokla is an associate professor at the department of Pharmaceutical Chemistry, Ain Shams University, Egypt. Her current research interest focuses on targeted cancer therapy and the development of novel antimicrobial agents. She has co-authored several peer-reviewed papers on the discovery and development of small-molecule kinase inhibitors targeting breast cancer and acute myeloid leukemia, and protein degraders targeting breast, lung, and oral squamous cell cancers. In this context, her work comprises drug discovery and medicinal chemistry efforts for small-molecule inhibitors’ development and optimization.

Publications

Results 1-20 of 23 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
127-Nov-2012Applying Ligands Profiling Using Multiple Extended Electron Distribution Based Field Templates and Feature Trees Similarity Searching in the Discovery of New Generation of Urea-Based Antineoplastic Kinase InhibitorsDokla, Eman ; Mahmoud, Amr H.; Elsayed, Mohamed S.A.; El-Khatib, Ahmed H.; Linscheid, Michael W.; Khaled A M Abouzid 
21-Dec-2013Ligand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino] phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino- acetamidobenzoic acid estersIsmail, Mohamed Abdel Hamid; Mohamed, Nasser Saad; Dokla, Eman ; Khaled A M Abouzid 
3Nov-2015Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) ActivatorsFang, Chun-Sheng; Lai, Po-Ting; Kulp, Samuel K; Serya, Rabah ; Ismail, Nasser S M; Chen, Ching-Shih; Dokla, Eman ; Khaled A M Abouzid 
41-Jul-2018A 5′ AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell CarcinomaWeng, Jing Ru; Dokla, Eman ; Bai, Li Yuan; Chen, Ching Shih; Chiu, Shih Jiuan; Shieh, Tzong Ming
52019Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluationShalaby, Menna-Allah; Dokla, Eman ; Serya, Rabah ; Abouzid, Khaled 
615-Nov-20191,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLCDokla, Eman ; Fang, Chun Sheng; Chen, Ching S.; Abouzid, Khaled 
715-Jan-2020Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteriaAbutaleb, Nader S; Milik, Sandra N; Li, Daoyi; El-Baz, Karim; Shalaby, Menna-Allah W; Al-Karaki, Rawan; Nasr, Maha ; Klein, Christian D; Seleem, Mohamed N; Dokla, Eman ; Khaled A M Abouzid 
89-Apr-2020Targeting YAP Degradation by a Novel 1,2,4-Oxadiazole Derivative via Restoration of the Function of the Hippo PathwayDokla, Eman ; Fang, Chun Sheng; Chu, Po Chen; Chang, Chih Shiang; Chen, Ching S.; Khaled A M Abouzid 
91-Aug-2020Penicillin binding protein 2a: An overview and a medicinal chemistry perspectiveShalaby, Menna-Allah W; Dokla, Eman ; Serya, Rabah ; Khaled A M Abouzid 
101-Dec-2021Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancerDokla, Eman ; Abdel-Aziz, Amal Kamal ; Milik, Sandra N.; Mahmoud, Amr H.; Saadeldin, Mona Kamal; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
1115-Feb-2022Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemiaDokla, Eman ; Abdel-Aziz, Amal Kamal ; Milik, Sandra N.; McPhillie, Martin J.; Minucci, Saverio; Khaled A M Abouzid 
121-Jun-2022Induction of apoptosis using ATN as a novel Yes-associated protein inhibitor in human oral squamous cell carcinoma cellsChu, Po Chen; Dokla, Eman ; Hu, Jing Lan; Weng, Jing Ru
13Dec-2022Discovery of EMD37, a 1,2,4-oxadiazole derivative, as a novel endoplasmic reticulum stress inducer with potent anticancer activityAbdel-Aziz, Amal Kamal ; Khaled A M Abouzid ; Minucci, Saverio; Dokla, Eman 
1422-Dec-2022SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteriaDokla, Eman ; Abutaleb, Nader S; Milik, Sandra N; Kandil, Ezzat A E A; Qassem, Omar M; Elgammal, Yehia; Nasr, Maha ; McPhillie, Martin J; Abouzid, Khaled A M; Seleem, Mohamed N; Imming, Peter; Adel, Mai
152023Nanoemulgel formulation of a benzimidazole derivative for wound healingRiham I. El-Gogary; Nada M. Abd-Elsaid; Mariam Gad; Reem K. Abd-Elhalim; Hana H. Habib; Wesam Eldeeb; Esraa R. Eldahshan; Salma H. Nassar; Aya N. Issa; Neveen Rabeh; Samar Abd-Elkhalik; Maha Nasr; Dokla, Eman 
162023AML and FLT3: An update on FDA-approved or under review kinase inhibitors targeting FLT3 kinaseNada Alaa El-Deen; Mai Jaballah; Abouzid, Khaled ; Dokla, Eman ; Serya, Rabah 
17Nov-2023FLT3 inhibitors and novel therapeutic strategies to reverse AML resistance: An updated comprehensive reviewAbdel-Aziz, Amal Kamal ; Saadeldin, Mona Kamal; Dokla, Eman 
182024FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectivesHeba M. Hesham; Eman Z. Elrazaz; Deena S. Lasheen; Dalal A. Abou El Ella; Dokla, Eman 
1915-Mar-2024Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cellsAbdel-Aziz, Amal Kamal ; Ahmed, Tarek E.; Hatem, Yasmin; Abdel Rahman, Engy A.; Sharaky, Marwa; Shahin, Mai I. ; Elrazaz, Eman Z.; Serya, Rabah A.T. ; Henary, Maged; Ali, Sameh S.; Abou El Ella, Dalal A.; Dokla, Eman ; Helmy, Sama 
202025Anticancer activity of EMD37 against human head and neck cancer: Impact on apoptotic and inflammatory machineriesMarwa Sharaky; Amal Kamal Abdel-Aziz; Dokla, Eman